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Related Experiment Videos

Cerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities study.

T H Mosley1, D S Knopman, D J Catellier

  • 1Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA. tmosley@medicine.umsmed.edu

Neurology
|June 30, 2005
PubMed
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Common brain changes like white matter hyperintensities and enlarged ventricles are linked to lower cognitive function in middle-aged adults. These findings highlight the impact of brain morphology on cognitive health.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Cerebral abnormalities on MRI are increasingly recognized in population studies.
  • Understanding the link between brain structure and cognitive function is crucial for middle-aged and aging populations.

Purpose of the Study:

  • To investigate the association between prevalent cerebral abnormalities detected via MRI and cognitive performance.
  • To analyze cognitive function in relation to white matter hyperintensities, ventricular size, and sulcal size in a middle-aged cohort.

Main Methods:

  • 1,538 individuals (aged 55-72) from the Atherosclerosis Risk in Communities (ARIC) cohort underwent MRI scans.
  • Trained neuroradiologists assessed white matter hyperintensities (WMHs), ventricular size, and sulcal size using a semiquantitative scale.

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  • Cognitive function was evaluated using the Delayed Word Recall Test (DWRT), Digit Symbol Substitution Test (DSST), and Word Fluency Test (WFT).

    • Main Results:

    • High ventricular grade correlated with lower DWRT and DSST scores and increased odds of impaired DWRT performance.
    • High sulcal grade was associated with a modest decrease in DWRT scores.
    • Coexisting high-grade WMHs and silent infarcts were linked to lower scores on all cognitive tests and higher odds of impaired DSST and WFT performance. The presence of two or more high-grade abnormalities independently predicted increased risk of impaired functioning across all cognitive tests.

    Conclusions:

    • Common cerebral morphological changes are associated with reduced cognitive functioning in middle-aged and young-elderly individuals.
    • These findings underscore the importance of brain health in maintaining cognitive abilities throughout aging.