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Relative elevation in baseline leukocyte count predicts first cerebral infarction.
M S V Elkind1, R R Sciacca, B Boden-Albala
1Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA. mse13@columbia.edu
Neurology
|June 30, 2005
Summary
Elevated white blood cell counts are linked to a higher risk of future ischemic stroke and cardiovascular events in stroke-free individuals. This finding highlights leukocyte count as a potential predictor for cardiovascular disease.
Area of Science:
- Cardiovascular Medicine
- Inflammatory Diseases
- Stroke Research
Background:
- Atherosclerosis is an inflammatory condition.
- Elevated leukocyte levels correlate with increased risk of ischemic heart disease.
Purpose of the Study:
- To determine if higher leukocyte counts predict future ischemic stroke (IS) in individuals without a history of stroke.
- To investigate the association between leukocyte count and subsequent cardiovascular events.
Main Methods:
- A population-based prospective cohort study involving 3,103 stroke-free participants.
- Leukocyte counts were measured at baseline, with annual follow-up for IS, myocardial infarction (MI), and mortality.
- Cox proportional hazards regression models were used for statistical analysis, adjusting for various risk factors.
Main Results:
- Each standard deviation increase in leukocyte count was associated with a 22% increased risk of IS.
- Individuals in the highest quartile of leukocyte count had a 75% increased risk of IS compared to the lowest quartile.
- Elevated leukocyte counts also predicted a combined risk of IS, MI, or vascular death.
Conclusions:
- Higher leukocyte counts are an independent risk factor for future ischemic stroke.
- Leukocyte count is associated with an increased risk of cardiovascular events, including IS and MI.