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Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human

Abiye H Iyo1, Bethany Porter, Evan S Deneris

  • 1Department of Psychiatry and Human Behavior, University of Mississippi, School of Medicine, Jackson, MS 39216, USA. aiyo@psychiatry.umsmed.edu

Synapse (New York, N.Y.)
|June 30, 2005
PubMed

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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing specific...