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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Acute pancreatitis in patients with ulcerative colitis
Hidekazu Inoue1, Katsuya Shiraki, Hiroshi Okano
1First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Acute pancreatitis is an occasional complication of ulcerative colitis (UC). This study found a 14% incidence of acute pancreatitis in UC patients, with some cases linked to medications like azathioprine and 5-ASA.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Extraintestinal manifestations (EIMs) can occur in UC patients.
Purpose of the Study:
- To determine the incidence of acute pancreatitis as an extraintestinal manifestation in patients with ulcerative colitis.
- To investigate the relationship between UC and acute pancreatitis episodes.
Main Methods:
- Retrospective evaluation of 22 ulcerative colitis patients.
- Follow-up period of 6 years (1989-2001).
- Diagnosis of acute pancreatitis based on clinical and laboratory findings.
Main Results:
- Three out of 22 patients (14%) developed acute pancreatitis.
- One patient had simultaneous onset of UC and acute pancreatitis.
- Two cases of drug-induced pancreatitis were identified (azathioprine, 5-ASA).
Conclusions:
- Acute pancreatitis is an occasional, not frequent, extraintestinal manifestation of ulcerative colitis.
- Medications used in UC treatment can be associated with pancreatitis.
- Further research may be needed to elucidate the exact mechanisms.
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