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Published on: October 2, 2016
Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum
Wayne W Harding1, Kevin Tidgewell, Matthew Schmidt
1Division of Medicinal & Natural Products Chemistry, The University of Iowa, Iowa City, 52242, USA.
Abstract:
[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.