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Controlling cell behavior electrically: current views and future potential.

Colin D McCaig1, Ann M Rajnicek, Bing Song

  • 1School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland. c.mccaig@abdn.ac.uk

Physiological Reviews
|July 1, 2005
PubMed
Summary
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Direct-current (DC) electric fields in animal tissues are crucial for development and regeneration but often overlooked. This review clarifies bioelectricity principles and explores therapeutic applications for tissue repair.

Area of Science:

  • Bioelectricity
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Direct-current (DC) electric fields are ubiquitous in developing and regenerating animal tissues.
  • The significance of these endogenous electric fields in tissue repair and development is largely underestimated.
  • Misconceptions and historical research limitations have hindered the study of bioelectricity.

Purpose of the Study:

  • To provide a comprehensive overview of bioelectricity.
  • To elucidate the fundamental principles governing DC electric fields in biological systems.
  • To explore the potential clinical applications of electric fields in tissue regeneration.

Main Methods:

  • Historical review of bioelectricity research.
  • Explanation of the physics and physiology underlying cellular electric fields.

Related Experiment Videos

  • Analysis of cellular mechanisms responding to electric fields.
  • Survey of clinical potential for electric field therapies.

    • Main Results:

    • DC electric fields play a fundamental role in cellular processes.
    • Understanding bioelectricity requires integrating physics, physiology, and cell biology.
    • Small electric fields can significantly influence cell behavior and tissue development.
    • Electric field stimulation shows promise for treating damaged epithelia and nervous system tissues.

    Conclusions:

    • Bioelectricity is a critical, yet underappreciated, factor in tissue development and regeneration.
    • Further research into bioelectric principles can unlock novel therapeutic strategies.
    • Harnessing endogenous electric fields offers a promising avenue for regenerative medicine and clinical treatments.