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Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated

Daniel K Tisi1, Xu-Jing Liu, Linda J Wykes

  • 1School of Dietetics and Human Nutrition, McGill University, Montreal, Canada.

The Journal of Nutrition
|July 1, 2005
PubMed

Insights

Second-trimester amniotic fluid (AF) insulin-like growth factor binding proteins (IGF BP) 1 and 3 may predict infant birth weight. Higher AF IGF BP1 correlated with lower birth weight, while AF IGF BP3 indicated higher birth weight in large-for-gestational-age infants.

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Fetal development

Background:

  • Fetal growth is influenced by amniotic fluid (AF) components, including growth factors.
  • Insulin-like growth factor II (IGF II) and its binding proteins (IGF BP) are crucial for fetal development.
  • Early pregnancy markers for fetal growth are valuable for clinical assessment.

Purpose of the Study:

  • To quantify insulin-like growth factor II (IGF II) and its binding proteins (IGF BP) 1 and 3 in second-trimester amniotic fluid (AF).
  • To determine if AF IGF II, IGF BP1, and IGF BP3 concentrations predict infant birth weight and classify fetal growth (small-for-gestational-age [SGA] or large-for-gestational-age [LGA]).

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure AF IGF II, IGF BP1, and IGF BP3.
  • Multivariate regression analysis controlled for maternal and infant variables.
  • Birth weight was categorized using standardized percentiles for SGA and LGA classification.

Main Results:

  • Higher AF IGF BP1 concentrations were associated with lower infant birth weight (partial r² = 0.0062).
  • AF IGF BP3 showed a positive association with birth weight in large-for-gestational-age (LGA) and macrosomia subpopulations (partial r² = 0.0283 and 0.0404, respectively).
  • IGF II levels were also assessed, though specific associations with birth weight categories were not detailed in the provided text.

Conclusions:

  • Second-trimester amniotic fluid IGF BP1 and IGF BP3 may serve as early predictive markers for fetal growth.
  • These findings suggest potential for non-invasive monitoring of fetal growth trajectories.
  • Further research could elucidate the precise roles of AF IGFs and IGF BPs in regulating fetal size.

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