[Mexidol in treatment of children with generalized epilepsy and febrile seizures]
G Natriashvili1, S Natriashvili, N Kapanadze
1Pediatric Clinic, Tbilisi State Medical University, Georgia.
Insights
Mexidol combined with Depakin improved epilepsy in 93% of children. As monotherapy, Mexidol normalized EEG patterns in 82% of children with febrile seizures, showing significant benefits for pediatric epilepsy and seizures.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacology
- Neurophysiology
Background:
- Epilepsy and febrile seizures are significant neurological conditions in children.
- Current treatments like Depakin chrono have limitations and side effects.
- Exploring adjunct therapies to improve treatment efficacy and EEG patterns is crucial.
Purpose of the Study:
- To evaluate the efficacy of Mexidol in treating generalized epilepsy in children.
- To assess Mexidol's role in normalizing electroencephalographic (EEG) patterns in pediatric epilepsy.
- To determine Mexidol's effectiveness as monotherapy for first-episode febrile seizures.
Main Methods:
- A study involving 120 children (4-16 years) with generalized epilepsy, treated with Depakin chrono +/- Mexidol.
- A separate cohort of 100 children (6 months-4 years) with first febrile seizures, treated with Mexidol monotherapy or no treatment.
- Computer EEG Topography "Brain Surveyor Saico" was used for electroencephalographic assessments.
Main Results:
- Combined Depakin and Mexidol treatment led to clinical improvement and EEG normalization in 93% of generalized epilepsy patients.
- Mexidol monotherapy normalized EEG patterns in 82% and improved them in 18% of children with febrile seizures.
- Control groups showed significantly lower EEG improvement rates (20%) and higher worsening (41%) or no effect (48%) in febrile seizures.
Conclusions:
- Mexidol, at 5 mg/kg, is effective when combined with Depakin for generalized epilepsy in children.
- Mexidol monotherapy demonstrates significant efficacy in normalizing EEG patterns for first-episode febrile seizures.
- Mexidol presents a promising therapeutic option for pediatric epilepsy and febrile seizure management.
Abstract:
The aim of our study was to estimate the role of Mexidol in ceasing of epileptic fits and improving electroencephalographic (EEG) pathological patterns in children. 120 patients with generalized epilepsy (from 4 to 16 years old) were investigated. All patients were treated by Depakin chrono 30 mg/kg. Children were divided into 2 groups: 1st--study group consisted of 60 children with combined treatment with Depakin and Mexidol (5 mg/kg). In the control group (60 children) treatment was performed only by Depakin. 100 children with the first episode of febrile seizures (from 6 months to 4 years old) were investigated. 50 children composed the study group with monotheraphy by Mexidol and 50 patients--the control group, without any treatment. The EEG examination was done by computer EEG Topography "Brain Surveyor Saico". Using Depakin in combination with Mexidol in the study group of patients with generalized epilepsy, improvement of clinical picture of disease and normalization of EEG patterns in 93% of cases has been observed. In the study group of patients with febrile seizures, normalization of EEG pathological patterns was observed in 82% cases and in 18% its improvement was seen. The relapse of seizures at high temperature was observed in 3 patients. In control group EEG patterns were improved only in 20%, in 48% no positive effect was observed and in 41% the worsening of EEG findings was seen. The relapse of febrile seizures was observed in 26 cases. Mexidol titrated to the target doze of 5mg/kg may be effective in combination with Depakin for treatment of patients with generalized epilepsy and as monotherapy in patients with first episode of febrile seizures.
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