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Catalase and PPARgamma2 genotype and risk of rheumatoid arthritis in Koreans

Ahmed El-Sohemy1, Marilyn C Cornelis, Yong-Wook Park

  • 1Department of Nutritional Sciences, University of Toronto, Toronto, Canada.

Rheumatology International
|July 1, 2005
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...