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Related Experiment Videos

Synthetic polymer systems in drug development.

C Alexander1

  • 1School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK. cameron.alexander@port.ac.uk

Expert Opinion on Emerging Drugs
|July 2, 2005
PubMed
Summary

Synthetic polymers are revolutionizing drug discovery by enabling efficient liquid-phase combinatorial synthesis. These polymer supports facilitate the creation of diverse chemical libraries for identifying novel therapeutic candidates.

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Area of Science:

  • Polymer Chemistry
  • Medicinal Chemistry
  • Organic Synthesis

Background:

  • Synthetic polymers with tunable solubility are increasingly used in drug discovery.
  • These polymers serve as key components in liquid-phase organic synthesis for generating compound libraries.

Purpose of the Study:

  • To review the application of synthetic polymers in drug discovery.
  • To discuss the advantages and challenges of polymer-supported synthesis, particularly liquid-phase combinatorial synthesis (LPCS).
  • To highlight therapeutic targets prepared using polymer-supported routes and discuss future trends.

Main Methods:

  • Review of literature on synthetic polymers in drug discovery.
  • Discussion of liquid-phase organic synthesis and combinatorial chemistry techniques.

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  • Analysis of polymer support development for therapeutic candidate preparation.

    • Main Results:

    • Linear polymers with differential solubilities are effective in liquid-phase organic synthesis.
    • LPCS offers advantages for generating diverse chemical libraries.
    • Several therapeutic targets have been successfully synthesized using polymer-supported methods.

    Conclusions:

    • Synthetic polymers are crucial for advancing drug discovery through efficient library generation.
    • Continued development of polymer supports is essential for overcoming challenges in parallel and combinatorial synthesis.
    • Polymer-supported synthesis holds significant potential for future drug discovery and development.