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The effects of green tea ingestion over four weeks on atherosclerotic markers
Heungsup Sung1, Won-Ki Min, Woochang Lee
1Department of Laboratory Medicine, Asan Medical Center and University of College of Medicine, 388-1 Pungnap-dong, Songpa-Gu, Seoul 138-736, South Korea.
Background:
The objective of this study was to evaluate the effects of green tea ingestion over four weeks on atherosclerotic biological markers.
Methods:
After a one-week baseline period, 12 healthy male volunteers aged 28--42 years drank 600 mL of green tea daily for four weeks. Lipid profile, oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), C-reactive protein (CRP) and soluble cell adhesion molecules were measured at baseline and after two and four weeks ingestion of green tea.
Results:
There was no significant change in the concentrations of lipid profile, TAC, CRP, soluble intercellular adhesion molecule-1 (sICAM-1), or soluble E-selectin after ingestion of green tea. The levels of ox-LDL and soluble vascular cell adhesion molecule-1 (sVCAM-1) were significantly decreased after four weeks of green tea ingestion (Wilcoxon signed rank test, P=0.006).
Conclusions:
The results of this study suggest an in vivo anti-oxidative effect for green tea and an influence of green tea on atherosclerotic biological markers. The effect of green tea seen on ox-LDL and sVCAM-1 provides a potential mechanism for the cardiovascular benefits of regular ingestion of green tea.
