Search research articles

Search research articles

Related Experiment Videos

Model for energy oscillations in cells.

Robert W Finkel¹

¹Department of Physics, St. John's University, Jamaica, NY 11439, USA. finkelr@stjohns.edu

Journal of Theoretical Biology

|July 2, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Directed cell migration from protrusion-adhesion coupling under local chemotactic regulation.

Journal of theoretical biology·2026

Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026

Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026

Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026

Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026

Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Cellular energy oscillations drive metabolic processes, influencing pulse rate and blood flow. This model explains Kleiber's law and frequency dependence on cell volume, revealing a common metabolic mechanism.

Area of Science:

Biophysics
Cell Biology
Theoretical Biology

Background:

Rapid periodic pulses observed in yeast cell walls suggest underlying coherent energy oscillations.
These energy oscillations are hypothesized to be a common feature across various cell types.

Purpose of the Study:

To explore consequences of small-amplitude chemical oscillations in cells.
To model energy oscillations as generic quantum oscillators and predict their behavior.
To derive established biological laws from a unified theoretical framework.

Main Methods:

Treating chemical oscillators as generic quantum oscillators.
Developing a model that predicts frequency dependence on cell volume.
Extending the model to multicellular organisms to derive Kleiber's law.

Related Experiment Videos

Main Results:

The model predicts higher frequencies in smaller cells, a simple volume-dependence.
It successfully derives Kleiber's law, including the numerical coefficient and mass exponent.
Established expressions for blood flow and pulse rate were derived.

Conclusions:

The proposed model for cellular energy oscillations aligns with diverse quantitative findings.
It suggests a common metabolic process underlying observed phenomena.
The model's success with minimal input and no free parameters supports its validity.