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Transitional cell carcinoma with rhabdoid features.

S Kumar1, D Kumar, D F Cowan

  • 1Department of Pathology, University of Texas Medical Branch, Galveston 77550.

The American Journal of Surgical Pathology
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study describes a rare renal pelvis cancer with rhabdoid and glandular features. The findings suggest some adult rhabdoid tumors may be variants of transitional cell carcinoma, not childhood renal rhabdoid tumors.

Area of Science:

  • Uropathology
  • Oncology
  • Cell Biology

Background:

  • Transitional cell carcinoma (TCC) of the renal pelvis can exhibit diverse morphologies.
  • Rhabdoid features in adult tumors are not well-characterized and their origin is debated.
  • Glandular metaplasia is an uncommon finding in renal pelvis TCC.

Observation:

  • A case of invasive transitional cell carcinoma of the renal pelvis with rhabdoid features and glandular metaplasia was analyzed.
  • In situ rhabdoid transformation of the transitional epithelium was observed, a novel finding.
  • Electron microscopy revealed whorled aggregates of intermediate filaments in rhabdoid cells.

Findings:

  • The tumor displayed both in situ and invasive components with rhabdoid features and glandular metaplasia.

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  • Electron microscopy confirmed intracellular lumina filled with mucin in both components.
  • Rhabdoid cells showed characteristic whorled aggregates of intermediate filaments.

    • Implications:

    • This case supports the concept that adult tumors with rhabdoid features may represent a heterogeneous group.
    • Some rhabdoid tumors might be unusual morphologic variants of transitional cell carcinoma.
    • This contrasts with the distinct clinicopathologic entity of childhood renal rhabdoid tumors.