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Risk for coronary artery disease and morbid preeclampsia: a commentary

Roberta B Ness1, Carl A Hubel

  • 1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. repro@pitt.edu

Annals of Epidemiology
|July 2, 2005
PubMed

Insights

Women with a predisposition to coronary artery disease (CAD) face higher risks for preeclampsia. Morbid preeclampsia significantly increases the likelihood of developing CAD later in life.

Area of Science:

  • Cardiovascular Medicine
  • Obstetrics
  • Public Health

Background:

  • Coronary artery disease (CAD) and preeclampsia share common risk factors.
  • Morbid preeclampsia, a severe form, poses significant public health challenges.

Purpose of the Study:

  • To review the established links between preeclampsia and CAD.
  • To identify shared risk factors and outcomes between these conditions.

Main Methods:

  • Literature review of published studies.
  • Analysis of common risk factors and associations.

Main Results:

  • Shared risk factors include obesity, hypertension, dyslipidemia, insulin resistance, hyperglycemia (Syndrome X), endothelial dysfunction, hyperuricemia, hyperhomocysteinemia, and inflammation.
  • Women with preeclampsia have an increased risk of developing CAD later in life.

Conclusions:

  • The association between CAD risk factors and preeclampsia is stronger in cases of morbid preeclampsia.
  • Women with morbid preeclampsia are at a heightened risk for developing CAD later in life.
Abstract

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