Predictors of response to cardiac resynchronization therapy (PROSPECT)--study design
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Updated: Aug 17, 2026
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Cheuk-Man Yu1, William T Abraham, Jeroen Bax
1Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. cmyu@cuhk.edu.hk
Insights
Predicting response to cardiac resynchronization therapy (CRT) is crucial. The PROSPECT study identifies echocardiographic measures to better select patients who will benefit from CRT, improving treatment outcomes.
Area of Science:
- Cardiology
- Medical Imaging
- Heart Failure Management
Background:
- Cardiac resynchronization therapy (CRT) is indicated for heart failure patients with wide QRS and left ventricular dysfunction.
- Current CRT criteria yield favorable responses in only two-thirds of eligible patients.
Purpose of the Study:
- To identify echocardiographic measures of dyssynchrony.
- To evaluate the predictive ability of these measures for CRT response.
Main Methods:
- The PROSPECT study is a prospective, multicenter, nonrandomized trial.
- Enrollment of ~300 patients across 75 centers globally.
- Testing conventional and tissue Doppler imaging parameters against clinical response criteria.
Main Results:
- Primary response criteria include improvement in the heart failure Clinical Composite Score.
- Secondary response criteria include left ventricular reverse remodeling.
Conclusions:
- The PROSPECT study aims to enhance patient selection for CRT.
- Identifying reliable echocardiographic predictors may optimize CRT efficacy and patient outcomes.
Background:
Cardiac resynchronization therapy (CRT) is currently indicated in patients with moderate to severe heart failure, a wide QRS complex and significant left ventricular dysfunction despite optimal medical therapy. Adoption of these criteria for CRT results in a favorable response in only two thirds of candidates.
Methods:
"Predictors of response to cardiac resynchronization therapy (PROSPECT)," a prospective, multicenter, nonrandomized study, aims to identify echocardiographic measures of dyssynchrony and evaluate their ability to predict response to CRT. PROSPECT will enroll approximately 300 patients in up to 75 centers in the United States, Asia, and Europe with clinical follow-up for 6 months. We will prospectively and individually test a variety of conventional echocardiographic and tissue Doppler imaging parameters against measures of clinical response. The primary response criteria are improvement in the heart failure Clinical Composite Score and left ventricular reverse remodeling. Enrollment began in March 2004 and is expected to conclude early 2005.
