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Predictors of response to cardiac resynchronization therapy (PROSPECT)--study design
Cheuk-Man Yu1, William T Abraham, Jeroen Bax
1Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. cmyu@cuhk.edu.hk
American Heart Journal
|July 2, 2005
Summary
Predicting response to cardiac resynchronization therapy (CRT) is crucial. The PROSPECT study identifies echocardiographic measures to better select patients who will benefit from CRT, improving treatment outcomes.
Area of Science:
- Cardiology
- Medical Imaging
- Heart Failure Management
Background:
- Cardiac resynchronization therapy (CRT) is indicated for heart failure patients with wide QRS and left ventricular dysfunction.
- Current CRT criteria yield favorable responses in only two-thirds of eligible patients.
Purpose of the Study:
- To identify echocardiographic measures of dyssynchrony.
- To evaluate the predictive ability of these measures for CRT response.
Main Methods:
- The PROSPECT study is a prospective, multicenter, nonrandomized trial.
- Enrollment of ~300 patients across 75 centers globally.
- Testing conventional and tissue Doppler imaging parameters against clinical response criteria.
Main Results:
- Primary response criteria include improvement in the heart failure Clinical Composite Score.
- Secondary response criteria include left ventricular reverse remodeling.
Conclusions:
- The PROSPECT study aims to enhance patient selection for CRT.
- Identifying reliable echocardiographic predictors may optimize CRT efficacy and patient outcomes.