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Dedifferentiated liposarcoma with extensive lymphoid component.

Cornelius Kuhnen1, Thomas Mentzel, Raf Sciot

  • 1Institute for Pathology, Limb tumor registry, Ruhr-University, University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, D- 44789 Bochum, Germany. cornelius.kuhnen@ruhr-uni-bochum.de

Pathology, Research and Practice
|July 5, 2005
PubMed
Summary
This summary is machine-generated.

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This study describes an unusual dedifferentiated liposarcoma variant with a significant lymphocytic component. The lymphoid infiltrate was found to be reactive, not neoplastic, a crucial distinction for diagnosis.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Dedifferentiated liposarcoma is a malignant soft tissue tumor.
  • Atypical lipomatous tumor/well-differentiated liposarcoma can dedifferentiate over time.
  • Unusual variants require careful diagnostic consideration.

Observation:

  • A case of dedifferentiated liposarcoma with extensive lymphocytic infiltration is presented.
  • The lymphoid component was morphologically distinct from the liposarcoma.
  • Immunohistochemistry and PCR revealed a polyclonal lymphocytic proliferation.

Findings:

  • Fluorescence in situ hybridization (FISH) showed no MDM2/CDK4 amplification in the lymphoid areas.
  • However, some mononuclear cells within the lymphoid population exhibited gene amplification, indicating dedifferentiated tumor cells.

Related Experiment Videos

  • The lymphoid infiltrate is likely reactive rather than neoplastic.

    • Implications:

    • This reactive lymphoid component can mimic a lymphoma, complicating the diagnosis of dedifferentiated liposarcoma.
    • Considering extensive lymphoid "overgrowth" is essential for the differential diagnosis of liposarcoma variants.
    • Understanding this variant aids in accurate diagnosis and treatment planning.