Animal models of psoriasis

Area of Science:

• Dermatology
• Immunology
• Genetics

Background:

• Psoriasis is a prevalent, chronic skin condition with complex pathophysiology.
• Understanding psoriasis's genetic basis and immune role has been hindered by the lack of suitable animal models.
• Previous limitations in animal models have impeded the development of effective psoriasis therapies.

Purpose of the Study:

• To review and critique existing animal models for psoriasis research.
• To assess the relevance of these models in understanding the immunogenetic underpinnings of psoriasis.
• To evaluate the utility of animal models for preclinical screening of novel psoriasis treatments.

Main Methods:

• Review of established and validated animal models for psoriasis.
• Analysis of models utilizing human skin engrafted onto severe combined immunodeficient (SCID) mice.
• Examination of other rodent models sharing features with psoriasis, without transplantation.

Main Results:

• The human skin-on-SCID mouse model is established and validated for psoriasis research.
• Several other rodent models exhibit partial similarities to psoriasis.
• These models offer varying degrees of relevance for studying psoriasis immunogenetics and treatment efficacy.

Conclusions:

• Validated animal models are crucial for advancing psoriasis research.
• The human skin-graft model and other rodent models provide valuable tools for preclinical studies.
• Continued development and application of these models are essential for elucidating psoriasis pathogenesis and therapeutic strategies.