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Related Experiment Videos

Risperidone (Risperdal): clinical experience with a new antipsychosis drug.

N A Keks1, C Culhane

  • 1Monash University, Mental Health Research Institute of Victoria, Alfred Hospital, Prahran 3181, Australia. N.Keks@alfred.org.au

Expert Opinion on Investigational Drugs
|July 5, 2005
PubMed
Summary

Risperidone effectively treats psychosis with fewer side effects than older drugs. This atypical antipsychotic offers improved tolerability and cost savings, making it a recommended first-line treatment.

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Area of Science:

  • Pharmacology
  • Psychiatry

Background:

  • Risperidone is a benzisoxazole derivative targeting serotonin 5-HT2 and dopamine D2 receptors.
  • It exhibits no anticholinergic effects, differentiating it from older neuroleptics.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of risperidone in treating psychotic symptoms.
  • To compare risperidone's pharmacoeconomic profile with older antipsychotic medications.

Main Methods:

  • Review of early studies and extensive post-marketing experience with risperidone.
  • Analysis of pharmacoeconomic studies and comparative efficacy trials.

Main Results:

  • Risperidone demonstrates efficacy for both positive and negative psychotic symptoms, with dose-dependent extrapyramidal side effects (EPS).

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  • Favorable tolerability is noted due to minimal sedation, limited weight gain, and absence of anticholinergic effects.
  • Associated with hyperprolactinemia, potentially causing amenorrhea and sexual dysfunction.
  • Pharmacoeconomic studies indicate reduced hospitalization and cost savings compared to older neuroleptics.
  • Equivalent efficacy to clozapine in treatment-resistant patients was observed.

    • Conclusions:

    • Risperidone is a well-tolerated and effective first-line treatment for psychoses.
    • Its favorable efficacy, tolerability, and cost-effectiveness support its widespread recommendation.