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Related Experiment Videos

Selenium-based drug design: rationale and therapeutic potential.

S W May1

  • 1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA. sheldon.may@chemistry.gatech.edu

Expert Opinion on Investigational Drugs
|July 5, 2005
PubMed
Summary

Selenium, an essential trace element, plays a crucial role in preventing diseases like cancer and heart disease. Research highlights its benefits, driving interest in selenium-based pharmaceuticals for various health conditions.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Pharmacology

Background:

  • Epidemiological studies link selenium deficiency to various diseases, including cancer, heart disease, arthritis, and AIDS.
  • Selenium has a long-standing association with human health and disease.
  • Emerging evidence supports beneficial effects of dietary selenium supplementation.

Purpose of the Study:

  • To explore the growing interest in selenium metabolism, pharmacology, and biology.
  • To highlight the role of selenium in various biological processes and its therapeutic potential.
  • To discuss the development of novel selenium-based pharmaceutical agents.

Main Methods:

  • Review of epidemiological findings and scientific literature on selenium.
  • Analysis of the molecular role of selenium in selenoproteins like glutathione peroxidase and thioredoxin reductase.

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  • Examination of ongoing research into selenium-based pharmaceutical development.

    • Main Results:

    • Selenium is an essential component of key enzymes (glutathione peroxidase, thioredoxin reductase) involved in cellular protection against oxidative damage.
    • Selenium's role extends to other mammalian selenoproteins, underscoring its biological significance.
    • Numerous novel pharmaceutical agents targeting selenium metabolism or utilizing selenium are under development.

    Conclusions:

    • Selenium's fundamental biological role is increasingly recognized, driving pharmaceutical innovation.
    • New selenium-based drugs are being developed for conditions including hypertension, cancer, viral infections, and immune disorders.
    • Future research is expected to yield more advanced selenium-based therapeutic strategies.