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Related Experiment Videos

Staphylococcal sepsis in a burns unit.

H A Lilly, E J Lowbury, M D Wilkins

    The Journal of Hygiene
    |December 1, 1979
    PubMed
    Summary

    An outbreak of staphylococcal sepsis in a burns unit was linked to Staphylococcus aureus. Phage type 95 strains with specific resistance patterns initiated the outbreak, potentially enhancing endemic strains.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Hospital Epidemiology

    Background:

    • Staphylococcal sepsis is a serious concern in healthcare settings, particularly burns units.
    • Historically, staphylococcal sepsis was infrequent in this specific burns unit.

    Purpose of the Study:

    • To investigate the characteristics and evolution of a staphylococcal sepsis outbreak.
    • To identify the microbial strains, resistance patterns, and phage types involved in the outbreak.
    • To understand the potential mechanisms driving the outbreak's progression.

    Main Methods:

    • Retrospective analysis of clinical data and microbial isolates from patients and staff.
    • Phage typing and antimicrobial susceptibility testing of Staphylococcus aureus strains.
    • Comparison of strains from different periods of the outbreak and from different infection sites (boils, blood, burns).

    Main Results:

    • The outbreak involved Staphylococcus aureus, with initial cases linked to penicillin, tetracycline, and erythromycin-resistant (PTE) strains of phage type 95.
    • While PTE/phage type 95 strains predominated early in the outbreak, other resistance patterns became more common later.
    • Endemic multiresistant strains (PTEKNML, phage pattern 29/77) and other staphylococci appeared to gain enhanced pathogenicity during the outbreak.

    Conclusions:

    • The outbreak was likely initiated by a specific strain of Staphylococcus aureus (phage type 95, PTE resistance).
    • The endemic strains may have acquired enhanced virulence through mechanisms like transduction from the epidemic strain.
    • This highlights the dynamic nature of microbial resistance and pathogenicity in hospital environments.

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