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Circulating activated T lymphocytes in autoeczematization.

J S Kasteler¹, M J Petersen, J E Vance

¹Department of Internal Medicine, Salt Lake City Veterans Affairs Medical Center, UT.

Archives of Dermatology

|June 1, 1992

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Activated T lymphocytes, indicated by HLA-DR and IL-2R, are elevated in autoeczematization and severe psoriasis, suggesting a role in disease pathogenesis. Treatment may reduce these markers.

Area of Science:

Immunology
Dermatology
Cell Biology

Background:

Autoeczematization etiology is unclear, with activated T lymphocytes proposed as a factor.
Cell surface markers like HLA-DR antigen and interleukin 2 receptor (IL-2R) indicate T lymphocyte activation.

Purpose of the Study:

To investigate the role of activated T lymphocytes in autoeczematization.
To compare T lymphocyte activation in autoeczematization, psoriasis, and stasis dermatitis.

Main Methods:

Flow cytometry measured T lymphocytes expressing HLA-DR or IL-2R.
Compared patients with autoeczematization, severe/mild psoriasis, and controls.

Main Results:

Elevated HLA-DR and IL-2R positive T lymphocytes in autoeczematization and severe psoriasis patients.

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Mild psoriasis patients showed no significant elevation.

Two autoeczematization patients showed reduced markers after treatment.

Conclusions:

Circulating activated T lymphocytes may play a role in autoeczematization pathogenesis.
Activated T lymphocytes might also be involved in severe psoriasis.