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Related Experiment Videos

Antifungal coating by biofunctionalized polyelectrolyte multilayered films.

Olivier Etienne1, Claire Gasnier, Corinne Taddei

  • 1Institut National de la Santé et de la Recherche Médicale, Unité 595, 11, rue Humann, 67085 Strasbourg Cedex, France.

Biomaterials
|July 5, 2005
PubMed
Summary

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This study introduces a novel antifungal coating for medical devices using a layer-by-layer technique and a peptide (chromofungin). The coating effectively inhibits fungal growth and shows promise for preventing device-related infections.

Area of Science:

  • Biomaterials Science
  • Mycology
  • Infectious Diseases

Background:

  • Medical device surfaces are prone to microbial adhesion, leading to biofilm formation and chronic infections.
  • Current strategies for preventing device-related infections include surface modifications.
  • Antifungal coatings are crucial for combating fungal pathogens on medical devices.

Purpose of the Study:

  • To develop and evaluate a novel topical antifungal coating for medical devices.
  • To functionalize a nanometric multilayer film with a chromogranin A-derived peptide (chromofungin).
  • To assess the efficacy and safety of the antifungal coating against common fungal pathogens.

Main Methods:

  • Layer-by-layer assembly technique to create nanometric multilayer films.

Related Experiment Videos

  • Functionalization of films with chromogranin A-derived antifungal peptide (CGA 47-66, chromofungin).
  • In vitro testing against Candida albicans and Neurospora crassa, and cytotoxicity assessment using human gingival fibroblasts.
  • In vivo evaluation in an oral candidiasis rat model using poly(methylmethacrylate) coated devices.

    • Main Results:

    • The embedded chromofungin peptide retained its antifungal activity, interacting with and penetrating fungal cells.
    • The antifungal coating inhibited Candida albicans growth by 65% and completely stopped Neurospora crassa proliferation in vitro.
    • Cytotoxicity assays showed no adverse effects on human gingival fibroblasts.
    • Successful in vivo testing of the antifungal coating on poly(methylmethacrylate) in a rat model of oral candidiasis.

    Conclusions:

    • Functionalized multilayer films incorporating chromofungin represent a promising strategy for local antifungal protection.
    • The developed coating is potent, non-toxic, and effective against key fungal pathogens.
    • This novel technique offers a new approach to preventing medical device-associated fungal infections.