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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
Imthyaz A Khan1, Manohar V Kulkarni, Chung-Ming Sun
1Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India.
Abstract:
A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 microg ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity.
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