Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvessel density does not predict outcome in high grade soft tissue sarcoma.

C C West1, N J Brown, D C Mangham

  • 1Academic Surgical Oncology Unit, Division of Clinical Sciences (South), Royal Hallamshire Hospital, University of Sheffield, K Floor, Sheffield S10 2JF, UK.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|July 5, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated Item Generation: impact of item variants on performance and standard setting.

BMC medical education·2023
Same author

The influence of candidates' physical attributes on patient ratings in simulated assessments of clinical practice.

Medical teacher·2022
Same author

A new species of <i>Proegernia</i> from the Namba Formation in South Australia and the early evolution and environment of Australian egerniine skinks.

Royal Society open science·2021
Same author

Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes.

The British journal of surgery·2021
Same author

Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

The British journal of surgery·2021
Same author

The influence of candidates' physical attributes on assessors' ratings in clinical practice.

Medical teacher·2021

Microvessel density (MVD) assessment in soft tissue sarcoma showed no correlation with patient prognosis. The Chalkley method is recommended for MVD quantification in these tumors.

Area of Science:

  • Oncology
  • Pathology
  • Vascular Biology

Background:

  • Tumor angiogenesis, the growth of new blood vessels, is crucial for malignant tumor progression.
  • Previous studies linked angiogenesis extent to prognosis in carcinomas, but not sarcomas.

Purpose of the Study:

  • To determine the best method for assessing microvessel density (MVD) in large, deep, high-grade soft tissue sarcomas.
  • To explore the relationship between MVD, vascular endothelial growth factor (VEGF) expression, and patient outcomes.

Main Methods:

  • Evaluated MVD in 42 soft tissue sarcoma patients using Chalkley count and total vessel count.
  • Assessed MVD in peripheral, central, necrotic, and hotspot tumor areas.
  • Quantified VEGF expression via immunohistochemistry.

Related Experiment Videos

Main Results:

  • The Chalkley method is recommended for MVD quantification.
  • Vascular endothelial growth factor (VEGF) expression did not correlate with MVD, metastasis, or survival.
  • Microvessel density correlated with histological subtype and primary tumor size but not metastasis or survival.

Conclusions:

  • Microvessel density is not a predictive factor for metastasis or survival in large, deep, high-grade soft tissue sarcomas.
  • Findings contrast with previous studies on carcinomas, highlighting sarcoma-specific angiogenesis behavior.