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In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Losses of 1p and chromosome 14 in renal oncocytomas
László Füzesi1, Derk Frank, Christian Nguyen
1Department of Pathology, Georg-August-Universität Gottingen, Robert-Koch-StraBe 40, Postfach 3032, Göttingen D-37075, Germany. fuezesi@med.uni-goettingen.de
Abstract:
We performed cytogenetic analyses of 8 renal oncocytomas to identify chromosomal regions involved in the tumorigenesis of oncocytomas. All cases showed chromosomal findings corresponding to established cytogenetic subsets of renal oncocytomas: 3 cases with normal karyotypes, 1 case with rearrangement of 11q, and 4 cases with losses of chromosome 14. In the latter cytogenetic subgroup, monosomy 14 was additionally accompanied by either monosomy 1 in 2 cases or loss of 1p in a third case, providing insights in the cytogenetic evolution of this subgroup.
Insights
Cytogenetic analysis of renal oncocytomas revealed specific chromosomal changes. Losses of chromosome 14 were observed in four cases, offering insights into tumor development.
Area of Science:
- Nephrology
- Oncology
- Cytogenetics
Background:
- Renal oncocytomas are benign kidney tumors.
- Understanding their genetic basis is crucial for diagnosis and management.
Purpose of the Study:
- To identify chromosomal abnormalities in renal oncocytomas.
- To correlate cytogenetic findings with tumor subsets.
Main Methods:
- Cytogenetic analysis was performed on 8 renal oncocytoma samples.
- Karyotyping was used to detect chromosomal alterations.
Main Results:
- Three cases (37.5%) had normal karyotypes.
- One case (12.5%) showed rearrangement of chromosome 11q.
- Four cases (50%) exhibited losses of chromosome 14, with some also showing monosomy 1 or 1p loss.
Conclusions:
- Cytogenetic analysis confirms distinct subsets of renal oncocytomas.
- Loss of chromosome 14 is a recurring finding in a significant subset.
- Further investigation into the cytogenetic evolution of these tumors is warranted.
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