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Related Experiment Videos

Osteocyte lacunae tissue strain in cortical bone.

Daniel P Nicolella1, Donald E Moravits, Adrian M Gale

  • 1Mechanical and Materials Engineering Division, Southwest Research Institute, San Antonio, TX, USA. dnicolella@swri.org

Journal of Biomechanics
|July 5, 2005
PubMed
Summary

Osteocytes, crucial for bone health, respond to mechanical signals. This study quantifies local bone matrix strains around osteocytes, revealing significantly amplified strains compared to overall bone strain.

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Area of Science:

  • Biomechanical Engineering
  • Cellular Biology
  • Orthopedics

Background:

  • Osteocytes are key regulators of bone modeling and remodeling.
  • The precise mechanical signals osteocytes detect remain largely unknown.
  • Current theories focus on perilacunar matrix deformation or fluid flow-generated shear stress.

Purpose of the Study:

  • To quantify local bone matrix strains experienced by osteocytes.
  • To investigate strains resulting from macroscopic bone loading in vivo.
  • To bridge the gap between macroscopic bone strain and cellular-level mechanical stimuli.

Main Methods:

  • Utilized digital image correlation (DIC) strain measurement technique.
  • Applied macroscopic bone strains similar to in vivo physiological levels (approx. 2000 microstrain).

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  • Measured and analyzed local bone matrix strains around osteocyte lacunae.

    • Main Results:

    • Local perilacunar bone matrix strains were significantly higher than macroscopic strains.
    • Peak local strains reached over 30,000 microstrain.
    • Average strain concentration factors ranged from 1.1 to 3.8, aligning with theoretical estimates.

    Conclusions:

    • Macroscopic bone strains are amplified locally around osteocytes.
    • These amplified strains likely represent the mechanical signals osteocytes respond to.
    • Findings enhance understanding of how bone cells sense and respond to functional loading.