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Updated: Aug 17, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol
Gloria V López1, Carlos Batthyány, Fabiana Blanco
1Departamento de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Abstract:
Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.
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