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Updated: Aug 17, 2026
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Two cases of non-Hodgkin's lymphoma presenting as primary gynecologic malignancies
James E Kendrick1, J Michael Straughn
1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 618 South 19th Street, Birmingham, AL 35233, USA. tommy.kendrick@obgyn.uab.edu
Background:
Non-Hodgkin's lymphoma (NHL) presenting as a gynecologic malignancy is exceedingly rare. We present two cases of NHL presenting as primary ovarian and cervical cancer, respectively.
Case:
A 66-year-old female presented with abdominal bloating and increased abdominal girth. She underwent a supracervical hysterectomy, bilateral salpingo-oophorectomy, and omentectomy for a large pelvic mass. Immunophenotyping/flow cytometry revealed monoclonal B-cells positive for the CD 20 marker, consistent with NHL. A 47-year-old female presented with persistent vaginal discharge and an ulcerative lesion of the cervix. Cervical biopsies were non-diagnostic for carcinoma but immunophenotyping demonstrated CD 20 positive B-cells, consistent with NHL.
Conclusion:
Although uncommon, lymphoma should be included in the differential diagnosis of gynecologic malignancies because of a favorable outcome when properly diagnosed and treated.
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