Related Experiment Videos
Systemic sclerosis and gastric MALT lymphoma
Laurent Arnaud1, Ariane Chryssostalis, Benoît Terris
1Service de Rhumatologie A, Hôpital Cochin, AP-HP, Université Paris V, France.
Joint Bone Spine
|July 5, 2005
Summary
A gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori infection resolved after H. pylori eradication therapy. This case highlights the effectiveness of antibiotic treatment for gastric MALT lymphoma.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gastric mucosa-associated lymphoid tissue (MALT) lymphomas are neoplasms of the stomach.
- These lymphomas are strongly associated with Helicobacter pylori infection.
- Clinical presentation is often nonspecific, with endoscopic findings including erythema or erosion.
Observation:
- A 76-year-old woman with systemic sclerosis presented with esophagitis.
- Endoscopy revealed grade III esophagitis and an gastric antral lesion.
- Biopsy confirmed a mucosa-associated lymphoid tissue (MALT) lymphoma, and tests were positive for Helicobacter pylori.
Findings:
- Staging investigations showed moderate mucosal infiltration via endoscopic ultrasonography.
- After successful H. pylori eradication treatment, a repeat endoscopy showed complete resolution of the gastric lesion.
- Histological examination is crucial for diagnosing MALT lymphoma, characterized by monoclonal B-cell infiltration.
Implications:
- Helicobacter pylori eradication is a primary treatment modality for gastric MALT lymphomas.
- This case demonstrates the potential for complete remission of gastric MALT lymphoma following H. pylori treatment.
- Early diagnosis and targeted therapy can lead to favorable outcomes in gastric MALT lymphoma.