Related Experiment Video
Updated: Feb 14, 2026
09:03
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
5.6K
Beyond the brush border: NHERF4 blazes new NHERF turf
William R Thelin1, Caleb A Hodson, Sharon L Milgram
1Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, CB 7090, Chapel Hill, NC 27599, USA.
The Journal of Physiology
|July 5, 2005
Summary
The Na exchanger regulatory factor (NHERF) family, particularly NHERF4, has distinct roles in epithelial cells. Further research is needed to fully understand NHERF4
Area of Science:
- Cell biology
- Molecular biology
- Biochemistry
Background:
- The Na exchanger regulatory factor (NHERF) family comprises epithelial-enriched PDZ domain scaffolding proteins crucial for epithelial cell function.
- NHERF proteins share overlapping tissue distribution and binding partners, hinting at potential functional redundancy within the family.
Framework:
- This review focuses on the distinct properties and unique cellular functions of individual NHERF proteins.
- Emphasis is placed on NHERF4, the most recently identified member, and its divergence from other NHERFs.
Implementation:
- Analysis of existing literature and experimental data on NHERF family members.
- Comparative assessment of NHERF protein distribution, binding interactions, and functional roles.
Implications:
- Each NHERF protein possesses unique characteristics leading to specialized cellular functions, despite some overlap.
- NHERF4 appears to be the most divergent member, necessitating further investigation into its specific role within the NHERF family context.
Related Concept Videos
00:57Carbohydrate Digestion
122.8K
Carbohydrate digestion and metabolism break down simple and complex carbohydrates from food into saccharides (i.e., sugars) for the body to use as energy. Carbohydrate digestion starts in the mouth during mastication, or chewing. The masticated carbohydrates remain intact in the stomach. Digestion resumes in the duodenum of the small intestine, where pancreatic alpha-amylase and brush border enzymes of the microvilli convert complex carbohydrates to monosaccharides. Finally, the monosaccharides...
122.8K
01:51Lampbrush Chromosomes
8.7K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
8.7K
01:34The Fluid Mosaic Model
180.2K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
180.2K
03:26Framing Effects
8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K