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Improvement in Cheyne-Stokes respiration following cardiac resynchronisation therapy
J Y Gabor1, D A Newman, V Barnard-Roberts
1Dept of Medicine, St. Michael's Hospital, University of Toronto, Canada.
The European Respiratory Journal
|July 5, 2005
Summary
Cardiac resynchronisation therapy (CRT) can reduce Cheyne-Stokes respiration (CSR) in heart failure patients. This improvement in breathing stability may enhance overall clinical outcomes for those undergoing CRT.
Area of Science:
- Cardiology
- Sleep Medicine
- Respiratory Medicine
Background:
- Cheyne-Stokes respiration (CSR) is a common breathing disorder in congestive heart failure (CHF) patients.
- CSR can worsen CHF prognosis and impact quality of life.
- Cardiac resynchronisation therapy (CRT) improves cardiac function in CHF.
Purpose of the Study:
- To investigate the effect of CRT on CSR severity in CHF patients.
- To determine if CRT stabilizes breathing control and reduces CSR.
Main Methods:
- 28 CHF patients eligible for CRT underwent baseline polysomnography.
- Patients received optimized medical treatment and CRT.
- Repeat polysomnography was performed after 6 months of CRT.
Main Results:
- 43% of patients (12/28) had significant CSR at baseline.
- 10 patients completed follow-up with successful CRT implantation.
- 6/10 patients showed a significant decrease in CSR severity post-CRT, linked to corrected hyperventilation and hypocapnia.
Conclusions:
- CRT is associated with a reduction in CSR severity in CHF patients.
- The observed improvement in CSR may contribute to better clinical outcomes.
- CRT may offer a therapeutic benefit for sleep-disordered breathing in CHF.