Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modafinil modulates anterior cingulate function in chronic schizophrenia.

Sean A Spence1, Russell D Green, Iain D Wilkinson

  • 1Sheffield Cognition and Neuroimaging, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK. s.a.spence@sheffield.ac.uk

The British Journal of Psychiatry : the Journal of Mental Science
|July 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Higher disease burden and greater small fibre impairment in women with painful diabetic neuropathy.

Pain reports·2026
Same author

Beyond pain relief: the effects of chronic opioid use on brain structure and function in diabetic neuropathy-a multimodal neuroimaging study.

Diabetologia·2025
Same author

Reduced Thalamic γ-Aminobutyric Acid (GABA) in Painless but Not Painful Diabetic Peripheral Neuropathy.

Diabetes·2024
Same author

Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy.

Diabetes care·2023
Same author

Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy: A magnetic resonance spectroscopy study.

Frontiers in pain research (Lausanne, Switzerland)·2023
Same author

The spin move to facilitate antegrade coronoid fixation in terrible triad injuries.

Journal of shoulder and elbow surgery·2022

Modafinil shows potential for improving cognitive deficits in schizophrenia by increasing brain activity in the anterior cingulate cortex. However, these cognitive benefits may only apply to a specific group of patients.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is characterized by significant cognitive impairments affecting social functioning.
  • Modafinil is known to promote wakefulness and has shown promise in enhancing cognitive abilities.

Purpose of the Study:

  • To investigate the immediate impact of modafinil on brain activity and cognitive performance in individuals with chronic schizophrenia.
  • To explore modafinil's effects on working memory and associated neural mechanisms.

Main Methods:

  • A randomized, double-blind, placebo-controlled crossover study was conducted.
  • 19 patients with chronic schizophrenia participated, receiving either 100 mg of modafinil or a placebo.
  • Functional magnetic resonance imaging (fMRI) was used during a working memory task.

Related Experiment Videos

Main Results:

  • Modafinil administration led to significantly increased activation in the anterior cingulate cortex during the working memory task.
  • The observed anterior cingulate cortex activity correlated with cognitive performance.
  • Cognitive enhancement was noted in only a subset of the study participants.

Conclusions:

  • Modafinil influences anterior cingulate cortex function in patients with chronic schizophrenia.
  • The cognitive benefits of modafinil may be limited to specific patient subgroups that require further identification and characterization.