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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Evidence of recombination between divergent hepatitis E viruses
Hélène van Cuyck1, Jun Fan, David L Robertson
1Etat Major des Armées, Maîtrise des Armements, Cellule d'analyse des risques biologiques it chimiques, Paris, France.
Abstract:
Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics.
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