Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for chronic osteomyelitis using Staphylococcus aureus in goats.

Christopher J Salgado1, Amir A Jamali, Samir Mardini

  • 1Plastic Surgery Section, Department of Surgery, William Beaumont Army Medical Center, El Paso, TX 79920-5001, USA. salgado_plastics@hotmail.com

Clinical Orthopaedics and Related Research
|July 5, 2005
PubMed
Summary

A new goat model for studying osteomyelitis (bone infection) shows high success rates and consistency. This large animal model offers a practical approach for research and treatment comparisons.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biparietal osteodystrophy: Nuances of clinical presentation and natural history.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Cumulative Incidence and Risk Factors for Secondary Alloplastic Cranioplasty: A Time-to-Event Analysis.

The Journal of craniofacial surgery·2026
Same author

Development and nested cross-validation of machine learning models for predicting transfusion requirements in pediatric craniosynostosis surgery.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Current Understanding and Craniofacial Considerations of Biparietal Osteodystrophy.

The Journal of craniofacial surgery·2026
Same author

Cancer Diagnoses in Patients With Cleft Lip and/or Palate: Increased Childhood Cancer Occurrence.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

National prevalence of postoperative opioid prescription following cleft palate repair.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026

Area of Science:

  • Veterinary Medicine
  • Orthopedics
  • Infectious Diseases

Background:

  • Traditional animal models for osteomyelitis (bone infection) present challenges including size, cost, and disease variability.
  • Limitations of existing models hinder effective research into osteomyelitis treatments.

Purpose of the Study:

  • To establish and validate a large animal model for osteomyelitis in goats.
  • To assess the clinical, radiographic, and histologic consistency of the induced osteomyelitis model.

Main Methods:

  • Tibial osteomyelitis was induced in 28 goats.
  • The model's efficacy was evaluated through bacterial isolation, clinical observation, radiography, and histology.
  • Complications and mortality rates were meticulously recorded.

Related Experiment Videos

Main Results:

  • Osteomyelitis was confirmed in 96% of animals (27/28) via radiographic and histologic evidence.
  • Staphylococcus aureus was isolated in 82% of cases, with histologic evidence present even without bacterial growth.
  • The model demonstrated a low complication rate (0%) and no mortality, with consistent disease progression.

Conclusions:

  • A goat model for tibial osteomyelitis is effective, reliable, and reproducible.
  • This large animal model minimizes common limitations, offering a practical platform for osteomyelitis research.
  • The model facilitates the study of osteomyelitis pathogenesis and the evaluation of novel treatment strategies.