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Related Experiment Videos

Post-Mohs micrographic surgical margin tissue evaluation with permanent histopathologic sections.

Ross M Campbell1, David Barrall, Caroline Wilkel

  • 1Department of Dermatology, Brown Medical School, Providence, Rhode Island 02906, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|July 6, 2005
PubMed
Summary

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Mohs surgery reliably ensures complete removal of facial skin cancers. Post-Mohs tissue evaluation confirmed the technique

Area of Science:

  • Dermatology
  • Oncology
  • Surgical Pathology

Background:

  • Incomplete resection of nonmelanoma skin cancer (NMSC) leads to high recurrence rates.
  • Mohs micrographic surgery (MMS) offers precise margin control for high-risk NMSC.
  • Accurate tumor margin assessment is crucial for preventing NMSC recurrence.

Observation:

  • This study evaluated the histologic accuracy of Mohs excision for facial skin cancers.
  • An additional tissue layer was examined via permanent histopathologic sections post-Mohs excision.
  • Two hundred ninety-six Mohs cases undergoing reconstruction were reviewed.

Findings:

  • Two cases of nodular basal cell cancer showed positive tumor involvement on post-Mohs permanent tissue.
  • Pathologic re-evaluation clarified one case as follicular epithelium and confirmed the other as residual tumor.

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  • These findings validate the accuracy of Mohs surgery in complete tumor excision.

    • Implications:

    • Mohs surgery demonstrates high reliability for margin control in skin cancer treatment.
    • This technique minimizes the risk of recurrent nonmelanoma skin cancer.
    • Accurate histopathologic assessment post-Mohs surgery is vital for treatment success.