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Pneumocystis: not just pneumonia
J Chad Peterson1, Melanie T Cushion
1Department of Infectious Disease, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560, USA.
Current Opinion in Microbiology
|July 6, 2005
Summary
Pneumocystis pneumonia (PCP) is now found in individuals without severe immune compromise, indicating new reservoirs and transmission routes. This fungus may also be a co-morbidity factor in various patient groups.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunology
Background:
- Pneumocystis spp. were historically linked to severe pneumonia in immunocompromised patients.
- Recent studies reveal asymptomatic carriage in non-immunocompromised individuals.
- The fungus has been detected in neonates, pregnant women, and those with chronic illnesses.
Purpose of the Study:
- To investigate the expanding spectrum of Pneumocystis spp. infections.
- To identify potential reservoirs and transmission dynamics of Pneumocystis.
- To explore the role of Pneumocystis as a co-morbidity factor.
Main Methods:
- Polymerase chain reaction (PCR) techniques were employed.
- Histological studies were conducted.
- Human and experimental animal models were utilized.
Main Results:
- Pneumocystis spp. identified in neonatal populations.
- Asymptomatic carriage detected in pregnant women and patients with chronic diseases.
- Evidence suggests potential reservoirs and transmission pathways.
Conclusions:
- Pneumocystis spp. have a broader host range than previously recognized.
- Understanding transmission is crucial for public health.
- Further research is needed on Pneumocystis as a co-morbidity factor.