Mammalian stress response: induction of the glucose-regulated protein family

The glucose-regulated protein family consists of a set of stress-inducible proteins localized in the endoplasmic reticulum. Since their discovery in 1977, significant advances in our understanding of their structure, function and regulation have been made. Recent findings concerning the physiological roles played by the glucose-regulated proteins, and their regulations at the transcriptional, post-transcriptional, translational and post-translational levels are summarized.