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Published on: November 29, 2019
Cerebrospinal fluid S-100B concentrations in normal and diseased cattle
Nobuaki Shimada1, Takamasa Inoue, Hideo Murata
1Department of Safety Research, National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
The Journal of Veterinary Medical Science
|July 6, 2005
Summary
Cerebrospinal fluid S-100B protein levels were measured in cattle. Elevated S-100B concentrations were observed in some diseased cattle without neurological signs, but its diagnostic utility remains inconclusive.
Area of Science:
- Veterinary Neurology
- Biomarker Discovery
- Cerebrospinal Fluid Analysis
Background:
- S-100B protein is a recognized marker for brain damage in humans.
- Its potential application in veterinary medicine, particularly in cattle, requires investigation.
- Inflammatory disorders can affect neurological function and protein levels in cerebrospinal fluid.
Purpose of the Study:
- To measure cerebrospinal fluid (CSF) S-100B concentrations in clinically normal and diseased cattle.
- To evaluate the correlation between CSF S-100B levels and inflammatory disorders in cattle.
- To determine the diagnostic utility of CSF S-100B for neurological conditions in cattle.
Main Methods:
- Cerebrospinal fluid (CSF) samples were collected from clinically normal cattle (n=15) and cattle with inflammatory disorders (n=43).
- Concentrations of S-100B protein were quantified in CSF samples.
- Statistical analysis was performed to compare S-100B levels between groups.
Main Results:
- Mean CSF S-100B levels were 2.9 +/- 1.6 ng/ml in normal cattle and 7.0 +/- 7.4 ng/ml in diseased cattle.
- Thirteen diseased cattle without neurological signs exhibited elevated S-100B (> 8.0 ng/ml).
- The two cattle with neurological disorders did not show elevated S-100B levels, and no specific disease was linked to increased S-100B.
Conclusions:
- Elevated CSF S-100B concentrations can occur in cattle with inflammatory disorders, even without apparent neurological signs.
- The diagnostic value of CSF S-100B for veterinary neurological diagnosis in cattle is currently inconclusive.
- Further research is needed to establish the role of S-100B as a reliable biomarker in bovine neurology.
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