Related Experiment Video
Updated: Aug 17, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Thromboembolic cerebral ischaemic attack complicating cardiac catheterization. Successful local thrombolytic therapy
M Krivokuca1, C Behrmann, M Sievert
1Department of Medicine III, University Hospital, Martin-Luther-University Halle-Wittenberg, 06097 Halle, Germany. mirko.krivokuca@medizin.uni-halle.de
Insights
Cerebral ischemia during cardiac catheterization can be treated. Local thrombolysis with reduced dose rt-PA successfully restored blood flow and resolved neurological symptoms in a patient.
Area of Science:
- Neurology
- Cardiology
- Radiology
Background:
- Cerebral ischemia is a potential complication of cardiac catheterization.
- Thromboembolism can cause cerebral ischemia during these procedures.
Observation:
- A patient experienced cerebral ischemia during cardiac catheterization.
- Initial CT scan ruled out cerebral hemorrhage.
Findings:
- Angiography revealed occlusion before the intracranial bifurcation of the right internal carotid artery.
- Local thrombolysis with a reduced dose of 34 mg recombinant tissue plasminogen activator (rt-PA) was administered.
- Post-thrombolysis angiography demonstrated restored perfusion and neurological symptom resolution.
Implications:
- This case highlights a successful treatment strategy for cerebral ischemia post-cardiac catheterization.
- Local thrombolysis with rt-PA is a viable option for managing such complications.
- Prompt diagnosis and intervention are crucial for favorable outcomes.
Abstract:
Cerebral ischaemia caused by thromboembolism is a possible complication of diagnostic and interventional cardiac catheterization. In this case report we describe the diagnostic steps and successful treatment strategy in the management of a patient who suffered from cerebral ischaemia during cardiac catheterization. Initial CT scanning to exclude cerebral haemorrhage was followed by angiography through the cardiac catheterization sheath in the right femoral artery. Occlusion just before the intracranial bifurcation of the right internal carotid artery was found and local thrombolysis given with a reduced dose of 34 mg rt-PA. The subsequent angiogram showed restored perfusion in the affected vessel after completion of thrombolytic therapy and resolution of neurological symptoms.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Transient Ischemic Attack l: Introduction
Ischemic Stroke l: Introduction
Peripheral Artery Disease III: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
