First aldehyde-functionalized poly(2-oxazoline)s for chemoselective ligation
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Updated: Aug 17, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Christian Taubmann1, Robert Luxenhofer, Sonia Cesana
1Lehrstuhl für Makromolekulare Stoffe, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
Abstract:
A protected aldehyde-functionalized 2-oxazoline, 2-[3-(1,3)-dioxolan-2-ylpropyl]-2-oxazoline (DPOx), was synthesized from commercially available compounds in high yields. The polymerization of DPOx with different initiators proceeds via a living ionic mechanism; thus, the polymers were of low polydispersity and the degree of polymerization could be precisely adjusted. Copolymerization with 2-methyl-2-oxazoline gave water-soluble statistical copolymers. Hydrolysis of the homo- and copolymers resulted in well-defined, aldehyde-bearing poly(2-oxazoline)s. The aldehyde side functions reacted quantitatively with an amino-oxy compound to form the corresponding oxime.
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