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[Relationship between plasma brain natriuretic peptide level and left ventricular systolic function in coronary
Rafał Celiński1, Anna Grzywa-Celińska, Witold Cholewiński
1Katedra i Zakłada Medycyny Nuklearnej Akademii Medycznej w Lublinie. celinscy@wp.pl
Insights
Brain natriuretic peptide (BNP) levels are higher in patients with coronary artery disease (CAD). BNP elevation in CAD correlates with left ventricular ejection fraction (LVEF) and peak emptying rate (PER), suggesting complex influences on cardiac function.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Coronary artery disease (CAD) affects millions globally, impacting cardiac function.
- Brain natriuretic peptide (BNP) is a biomarker associated with heart failure and cardiac stress.
Purpose of the Study:
- To measure plasma BNP concentrations in patients with CAD.
- To investigate the relationship between BNP levels and left ventricular (LV) systolic function parameters, specifically LVEF and PER.
Main Methods:
- Gated equilibrium radionuclide ventriculography was performed on 69 CAD patients and 18 healthy controls.
- Left ventricular ejection fraction (LVEF) and peak emptying rate (PER) were calculated.
- Plasma BNP concentrations were measured and compared between groups.
Main Results:
- Patients with CAD exhibited significantly higher BNP concentrations and frequency compared to controls.
- BNP levels were significantly elevated in CAD patients with decreased LVEF (dLVEF) compared to those with normal LVEF (nLVEF).
- A statistically significant, though not strong, correlation was observed between BNP levels and both LVEF and PER.
Conclusions:
- Elevated plasma BNP in CAD patients is influenced by both myocardial contraction and LV emptying dynamics.
- Further research is needed to understand BNP elevation in CAD patients with normal EF but reduced LV ejection rate.
Unlabelled:
THE AIM of the study was to assess the brain natriuretic peptide (BNP) plasma concentrations in patients with CAD and to evaluate the relationships between BNP levels and such parameters of the left ventricular (LV) systolic function as ejection fraction (LVEF) and peak LV emptying rates (PER).
Material And Methods:
The study population comprised 69 patients with CAD, aged 30-79 years. All subjects underwent gated equilibrium radionuclide ventriculography at rest. From the data acquired, LVEF and PER were calculated. The plasma BNP concentrations were determined in blood samples taken from patients with CAD and in 18 healthy subjects and the obtained results were compared with those by radionuclide ventriculography. For this purpose patients with CAD were divided into two subgroups: dLVEF (LVEF<50%) and nLVEF (LVEF>50%). Subjects with normal LVEF (nLVEF) were divided into subgroups with PER greater than median value of this parameter and lower than or equal to the median.
Results:
In patients with CAD both the BNP concentration and its frequency were significantly higher than in controls. In patients with CAD and dLVEF the BNP concentration was significantly higher than in nLVEF cases. Increased BNP concentration was distinctly more frequent in dLVEF group than in nLVEF, but the difference was not significant (p>0.05). In group with nLVEF, the BNP concentration was higher in patients with PER<2.33 (dPER) in comparison to those with PER>2.3 (p>0.05). Not very close, but statistically significant correlation was found between the BNP level on the one hand and the LVEF and PER on the other.
Conclusions:
Increased plasma BNP in patients with CAD seem to depend not only on the degree of the myocardial contraction, but also on the dynamics of the left ventricular emptying. The reason for the BNP elevation in cases with CAD and reduced LV ejection rate but normal EF needs to be investigated.
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