[Can vulvar carcinoma be a danger in the 21st century?]

Vulvar carcinoma accounts for 3-5% of all genital cancers. The most common histology of vulvar cancer is squamous cell carcinoma. It has been suggested that vulvar cancer exists as two separate diseases--HPV-positive, occurring in young women, and p53-positive, that occurs in older women. As extensive surgery resection is gold standard of treatment, it is important to play attention for all symptoms, suggesting the beginning of disease. Understanding of the anatomy and the mechanism of lymphatic spread have made modifications in surgical technique possible, allowing less radical excisions.