Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-penetrating peptides: [corrected] from inception to application.

Mazin Magzoub1, Astrid Gräslund

  • 1Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, S- 106 91 Stockholm, Sweden.

Quarterly Reviews of Biophysics
|July 7, 2005
PubMed
Summary

Cell-penetrating peptides (CPPs) facilitate the delivery of therapeutic macromolecules into cells. This review explores CPPs, their applications, and the ongoing debate surrounding their translocation mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prion Protein-Derived Cell-Penetrating Peptide Inhibits Type II Diabetes-Associated Islet Amyloid Polypeptide Aggregation and Cytotoxicity.

Biochemistry·2026
Same author

Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.

Science translational medicine·2026
Same author

Binding of ApoE Isoforms to Aβ Peptides and Effects on Their Fibrillization.

ACS omega·2026
Same author

LL-37 and Its Truncated Fragments Modulate Amyloid-β Dynamics, Aggregation and Toxicity Through Hetero-Oligomer and Cluster Formation.

Angewandte Chemie (International ed. in English)·2025
Same author

Secondary Structures of Human Calcitonin at Different Temperatures and in Different Membrane-Mimicking Environments, Characterized by Circular Dichroism (CD) Spectroscopy.

ACS omega·2025
Same author

Binding of Hg(I) and Hg(II) Ions to Amyloid-Beta (Aβ) Peptide Variants Affect their Structure and Aggregation.

Chembiochem : a European journal of chemical biology·2025

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biophysics

Background:

  • Therapeutic macromolecules face challenges in crossing cell membranes.
  • Cell-penetrating peptides (CPPs) offer a solution for efficient cellular delivery.
  • Understanding CPP translocation mechanisms is crucial for therapeutic development.

Purpose of the Study:

  • To review the history and applications of CPPs.
  • To discuss the mechanisms of CPP translocation.
  • To highlight controversies and recent evidence regarding CPP uptake.

Main Methods:

  • Literature review of CPP research.
  • Analysis of studies on CPP translocation mechanisms.
  • Discussion of biophysical and biochemical evidence.

Related Experiment Videos

Main Results:

  • CPPs are effective in delivering various cargoes into cells in vitro and in vivo.
  • Initial proposed mechanisms of CPP translocation (non-endocytotic, ATP-independent) are debated.
  • Recent evidence necessitates re-evaluation of CPP uptake pathways.

Conclusions:

  • CPPs represent a significant advancement in drug delivery.
  • The precise mechanism of CPP translocation remains an active area of research and controversy.
  • Further investigation is needed to fully elucidate CPP uptake for optimized therapeutic strategies.