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Related Experiment Videos

Comparative evaporimetry in man.

Jigna H Shah1, Hongbo Zhai, Howard I Maibach

  • 1Department of Dermatology, University of California, San Francisco, CA 94143-0989, USA.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|July 7, 2005
PubMed
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A new closed chamber device for measuring transepidermal water loss (TEWL) showed comparable results to traditional open chamber devices on forearms, but higher readings on foreheads. Both methods are robust for skin barrier assessment.

Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Skin Physiology

Background:

  • Transepidermal water loss (TEWL) is a key indicator of skin barrier function.
  • Traditional open-chamber devices for TEWL measurement have limitations due to airflow and probe size.
  • A novel portable closed-chamber Evaporimeter offers potential advantages in reducing external measurement influences.

Purpose of the Study:

  • To compare the performance of a new closed-chamber Evaporimeter with traditional open-chamber devices for TEWL measurement.
  • To evaluate the reliability and consistency of TEWL measurements across different skin sites.

Main Methods:

  • Simultaneous TEWL measurements were conducted using two open-chamber and one closed-chamber device.
  • Measurements were performed on seven distinct locations on the forearms and foreheads of healthy volunteers.

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  • Experimental conditions, including relative humidity and temperature, were kept consistent for all instruments.

    • Main Results:

    • No statistically significant differences in TEWL values were found between the instruments for forearm measurements.
    • A significant difference was observed for forehead measurements, with the closed-chamber device yielding higher TEWL values.
    • TEWL measurements from all instruments demonstrated consistency with small standard deviations.

    Conclusions:

    • Both open- and closed-chamber devices provide robust and consistent TEWL measurements.
    • The closed-chamber method may offer increased utility due to its ease of use.
    • Further standardization efforts can document similarities and differences between TEWL measurement techniques.