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Updated: Aug 17, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
Validation and refinement of gene-regulatory pathways on a network of physical interactions
Chen-Hsiang Yeang1, H Craig Mak, Scott McCuine
1Center for Biomolecular Science and Engineering, Baskin School of Engineering, University of California, Santa Cruz, CA 95064, USA. chyeang@soe.ucsc.edu
Abstract:
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. Using this procedure, we evaluate 38 candidate regulatory networks in yeast and perform four high-priority gene knockout experiments. The refined networks support previously unknown regulatory mechanisms downstream of SOK2 and SWI4.
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