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Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study

Christina Ellervik1, Anne Tybjaerg-Hansen, Peer Grande

  • 1Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark.

Circulation
|July 7, 2005
PubMed

Insights

Hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, and C282Y/wild-type were not linked to increased risk of ischemic heart disease (IHD) or myocardial infarction (MI). However, the study couldn't rule out a modest risk increase for some genotypes.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Public Health

Background:

  • Hereditary hemochromatosis is a genetic disorder.
  • Specific genotypes (C282Y/C282Y, C282Y/H63D, C282Y/wild-type) are associated with iron overload.
  • The link between these genotypes and ischemic heart disease (IHD) or myocardial infarction (MI) requires investigation.

Purpose of the Study:

  • To test the hypothesis that hereditary hemochromatosis genotypes are risk factors for IHD and MI.
  • To evaluate the association between C282Y/C282Y, C282Y/H63D, and C282Y/wild-type genotypes and the risk of IHD and MI.

Main Methods:

  • A prospective study of 9178 Danish individuals followed for 24 years.
  • A case-control study involving 2441 IHD and 1113 MI cases versus 8080 controls.
  • Statistical analysis to determine hazard ratios and odds ratios for IHD and MI associated with specific genotypes.

Main Results:

  • No significant association was found between C282Y/C282Y, C282Y/H63D, or C282Y/wild-type genotypes and increased risk of IHD or MI in prospective studies.
  • Case-control studies also revealed no association between these genotypes and increased risk of IHD or MI.
  • The study had 90% power to detect hazard ratios of 3.4 for C282Y/C282Y and 1.9 for C282Y/H63D.

Conclusions:

  • Hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, and C282Y/wild-type are not associated with IHD or MI in this population.
  • The study lacked sufficient power to exclude a modest increased risk of IHD or MI for C282Y/C282Y and C282Y/H63D genotypes.
Abstract

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