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Updated: Aug 17, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
That which does not kill you makes you stronger: a molecular mechanism for preconditioning
Jonathan E McDunn1, J Perren Cobb
1Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract:
Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.
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