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Related Experiment Videos

The MicrobesOnline Web site for comparative genomics.

Eric J Alm1, Katherine H Huang, Morgan N Price

  • 1Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Genome Research
|July 7, 2005
PubMed
Summary

MicrobesOnline offers free, web-based comparative genomic tools for prokaryotes, aiding research with operon predictions and genome analysis. This platform supports microbial genomics by providing accessible data and analysis functionalities for the scientific community.

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Area of Science:

  • Microbial genomics
  • Bioinformatics
  • Computational biology

Background:

  • Hundreds of microbial genomes are sequenced, with more in progress.
  • Comparative genomics is crucial for understanding microbial life.

Purpose of the Study:

  • To introduce MicrobesOnline, a suite of web-based comparative genomic tools.
  • To facilitate multispecies comparisons among prokaryotes.

Main Methods:

  • Development of a publicly available, web-based platform.
  • Integration of tools for operon and regulon predictions.
  • Inclusion of multispecies genome and Gene Ontology browsers.
  • Comparative KEGG metabolic pathway viewer and Bioinformatics Workbench.

Main Results:

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  • MicrobesOnline provides operon and regulon predictions.
  • Features include multispecies genome and Gene Ontology browsers.
  • Comparative pathway analysis and sequence analysis tools are available.

Conclusions:

  • MicrobesOnline is a valuable, freely accessible resource for microbial genomics research.
  • The platform supports in-depth sequence analysis and gene of interest tracking.
  • Facilitates comparative genomic studies across multiple prokaryotic species.