Related Experiment Videos
Monocyte function-associated antigen expression during and after pediatric cardiac surgery.
Peter Gessler1, Rene Pretre, Christoph Bürki
1Divisions of Pediatric Intensive Care Medicine, University Children's Hospital of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. peter.gessler@kispi.unizh.ch
The Journal of Thoracic and Cardiovascular Surgery
|July 7, 2005
Summary
Monocyte receptor expression changes after pediatric cardiac surgery, indicating early activation and subsequent anti-inflammatory responses. Monitoring monocyte function pre-surgery may predict infection risk.
Area of Science:
- Immunology
- Pediatric Cardiology
- Surgical Inflammation
Background:
- Systemic inflammatory response syndrome and infections are significant risks post-cardiopulmonary bypass.
- The balance of inflammatory mediators is crucial in adult post-cardiac surgery outcomes.
- Monocyte receptor expression may indicate the body's inflammatory response to surgery.
Purpose of the Study:
- To investigate monocyte function-related receptor expression in children undergoing cardiac surgery.
- To correlate monocyte receptor changes with inflammatory mediators and clinical outcomes.
- To assess if pre-surgical monocyte function can predict post-operative infectious complications.
Main Methods:
- Prospective observational study in 40 children undergoing elective cardiac surgery.
- Assessed monocyte surface receptor expression before, during, and after surgery.
- Correlated receptor expression with plasma levels of inflammatory mediators like monocyte chemotactic protein 1 and interleukin 10.
Main Results:
- Monocyte activation observed via changes in chemokine receptor CCR2 expression, inversely correlated with monocyte chemotactic protein 1.
- High monocyte chemotactic protein 1 levels linked to increased CD11b/CD18 expression.
- Human leukocyte antigen DR expression decreased post-cardiopulmonary bypass, correlating with higher interleukin 10.
- Lower pre-surgical human leukocyte antigen DR expression predicted post-operative bacterial pneumonia.
Conclusions:
- Monocyte function-related receptor expression is significantly altered following pediatric cardiac surgery.
- Early monocyte activation by monocyte chemotactic protein 1 is followed by an anti-inflammatory response.
- Pre-operative assessment of monocyte function may help anticipate the risk of bacterial infection.