Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal temperature for selective cerebral perfusion.

Justus T Strauch1, David Spielvogel, Alexander Lauten

  • 1Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York University, NY, USA. ju.strauch@gmx.de

The Journal of Thoracic and Cardiovascular Surgery
|July 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary Outcomes of Temporary Mechanical Circulatory Support Use in Ischemic Ventricular Septal Defect: A U.S. Multi-Center Analysis.

The Annals of thoracic surgery·2026
Same author

Two variations of Commando-Nicks approach for calcified aortic and mitral valve disease.

Multimedia manual of cardiothoracic surgery : MMCTS·2026
Same author

Intraprocedural Findings and Outcomes of Redo Procedures After Voltage-Guided Ablation of Persistent Atrial Fibrillation.

Journal of clinical medicine·2026
Same author

Incidence and Management of Access Site Infection Following Trans-Axillary Implant of a Microaxial Left Ventricular Assist Device.

Artificial organs·2026
Same author

Characteristics and outcomes of patients with heart failure and reduced left ventricular ejection fraction in relation to sodium-glucose cotransporter-2 inhibitor treatment: real-world data from the multicentre H<sup>2</sup>-registry.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Balloon Postdilation After Transcatheter Aortic Valve Implantation (TAVI) Among Self- and Balloon-Expandable Valves: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2025

Lower temperatures (10-15°C) during selective cerebral perfusion offer superior brain protection compared to higher temperatures (20-25°C) in arch surgery, despite lower oxygen consumption. This finding impacts optimal strategies for cerebral protection during complex cardiovascular procedures.

Area of Science:

  • Cardiovascular Surgery
  • Neurology
  • Physiology

Background:

  • Hypothermic circulatory arrest and selective cerebral perfusion are used for brain protection during aortic arch surgery.
  • Optimal temperature for selective cerebral perfusion remains debated, impacting neurologic outcomes.

Purpose of the Study:

  • To investigate the impact of different selective cerebral perfusion temperatures on cerebral metabolism and neurologic outcomes.
  • To determine the ideal temperature range for selective cerebral perfusion during aortic arch surgery.

Main Methods:

  • A blinded study involving 40 pigs randomized into four groups, each undergoing hypothermic circulatory arrest at 20°C followed by selective cerebral perfusion at 10°C, 15°C, 20°C, or 25°C for 60 minutes.
  • Cerebral blood flow, hemodynamics, intracranial pressure, cerebrovascular resistance, oxygen consumption, and postoperative behavioral scores were monitored.

Related Experiment Videos

Main Results:

  • Cerebral blood flow was significantly higher during selective cerebral perfusion and recovery at 20°C-25°C compared to 10°C-15°C.
  • Oxygen consumption remained significantly lower throughout perfusion and recovery at 10°C-15°C compared to 20°C-25°C.
  • Postoperative behavioral scores were significantly better in pigs perfused at 10°C-15°C.

Conclusions:

  • Selective cerebral perfusion at 10°C-15°C provides superior cerebral protection compared to 20°C-25°C.
  • Lower temperatures during selective cerebral perfusion improve neurologic outcomes, even with sustained low oxygen consumption.
  • A rapid return of metabolism does not guarantee a better behavioral outcome after hypothermic circulatory arrest and selective cerebral perfusion.